Chemoproteomic and structural analyses revealed that TSN interacts with Hck and Lyn to abrogate suppressive macrophage immunity. Our functional screen of genetically probed macrophages with a chemical library identifies that TSN reverses macrophage-mediated tumor immunosuppression, leading to enhanced T cell infiltration, activation, and reduced exhaustion. Here, we report that toosendanin (TSN), a small-molecule compound, reprograms macrophages to enforce antitumor immunity in glioblastoma (GBM) in mouse models. This immune suppressive tumor microenvironment is largely driven by tumor-associated myeloid cells, including macrophages. Thank you for your patience.T cell–based immunotherapy holds promise for treating solid tumors, but its therapeutic efficacy is limited by intratumoral immune suppression. NOTE: Technical Support is ONLY available Monday - Friday (9 am to 5 pm Central European Time), it can take a few days to get a response depending on the level of demand. We are happy to work this way, no need to worry. Short simple sentences in your original language translate best. Use English - Google Translate your post.Include mp4 videos to your post from the 'Attachments' tab, at the bottom of the post edit window. Windows 10 includes an integrated screen recorder, see here OR get a free free recorder here. A video - The best way of demonstrating many issues.Include images using the 'Attachments' tab, at the bottom of the post edit window. Screenshots - Another great way to demonstrate issues.Specific information - a) FL Studio version & build number, b) what you are doing and what happens exactly, c) step-by-step instructions how reproduce the problem.Simple clear explanation - Explain what you are doing, or trying to do, and exactly what is happening.Install the latest version for any you spot.
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